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摘要：
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摘要：肝硬化是各种肝脏疾病的终末阶段，肝硬化能否逆转已争议多年，越来越多的
证据表明，肝硬化在去除病因、得到有效治疗后可发生一定程度的逆转。肝纤维化是
各种慢性肝病发展为肝硬化的重要中间环节，具有修复和损伤双重性，肝纤维化可进
一步发展为肝硬化甚至肝癌，严重威胁患者生命。因此，肝纤维化逆转的研究对于临
床诊治具有重要的指导意义。动物实验是生物医学研究的基本手段之一，也是连接基
础研究和临床试验的重要桥梁，本文总结不同动物模型包括化学损伤性肝纤维化逆转模
型、胆管结扎肝纤维化逆转模型和非酒精性脂肪性肝纤维化逆转模型等，通过归纳不同
动物模型的优点与局限性，为肝纤维化逆转研究提供依据，以更好地指导临床实践。
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Abstract: Liver cirrhosis is the final stage of various liver diseases. Whether liver cirrhosis can be reversed
has been debated for many years. More and more evidence showed that liver cirrhosis could be reversed to
a certain extent after removing the etiology and receiving effective treatment. Liver fibrosis is an important
intermediate link in the development of various chronic liver diseases into liver cirrhosis. It has the dual
nature of repair and injury, and liver fibrosis can furtherly develop into liver cirrhosis and even liver cancer,
and it is a serious threat to the patients. Therefore, the study of liver fibrosis reversal put a very important
guiding significance to the diagnosis and treatment of clinical patients with liver cirrhosis. Animal
experiment is not only one of the basic means of biomedical research, but also an important bridge between
basic research and clinical trials. This paper summarized different animal models, including chemical injury
liver fibrosis reversal model, bile duct ligation liver fibrosis reversal model and non-alcoholic fatty liver
fibrosis reversal model by summarizing the advantages and limitations of different animal models, and
provide evidence for reversal study of liver fibrosis to better guide clinical practice.
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