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摘要：
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摘要：自1994年被发现以来，瘦素为研究脂肪组织和内分泌器官生理功能等奠定了重
要基础。瘦素与肝功能密切相关，在许多代谢途径中发挥多种作用。了解脂肪组织和
肝脏间的新陈代谢及与激素间的相互作用将为慢性肝脏疾病的治疗提供新的方向。瘦
素通过直接调节中枢神经系统影响肝脏代谢，本文重点阐述了瘦素对非酒精性脂肪性
肝病发病机制的影响，总结了瘦素对肝脏部分切除术后肝脏再生过程的影响以及用于
治疗某些肝脏恶性肿瘤。
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Abstract: Since its discovery in 1994, leptin has laid an important foundation for other studies on the
physiological function of adipose tissue and endocrine organs. Leptin is closely related to liver function
and plays a number of roles in many metabolic pathways. Understanding the metabolism between
adipose tissue and the liver and its interactions with hormones will provide new directions for the
treatment of chronic liver diseases. Leptin affects the liver metabolism by directly regulating the central
nervous system, this article focused on the effects of leptin on the pathogenesis of non-alcoholic fatty
liver disease and summarized the effects of leptin on liver regeneration after hepatectomy and the use in
the treatment of some malignant liver tumors.
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