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摘要：
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摘要：肝硬化是几种神经精神疾病的重要危险因素，肝硬化患者患肝性脑病、阿尔茨海默
病和帕金森病等神经退行性疾病以及焦虑和抑郁等情绪障碍的风险较高。近年来，研究人
员越来越关注肠道和肝脏、中枢神经系统间的交流以及这些器官功能相互影响的方式，这
种双向交流被称为肠-肝-脑轴。肠道微生物群已成为影响肠-肝、肠-脑和脑-肝交流的关键
机制。对微生物群-肠-肝-脑轴的研究有利于加深对肝硬化相关神经精神疾病发病机制的认
识，也可为新型治疗方法提供方向。本文总结了肠道微生物失调与肝硬化相关神经精神疾
病的联系以及目前临床和临床前研究中以调节肠道微生物群作为治疗方法的证据。
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Abstract: Liver cirrhosis is a significant risk factor for several neuropsychiatric conditions. Patients
with liver cirrhosis are at higher risk of neurodegenerative diseases such as hepatic encephalopathy,
Alzheimer’s disease and Parkinson’s disease, as well as emotional disorders such as anxiety and
depression. In recent years, researchers have increasingly focused on the communication between
gut, liver and the central nervous system, as well as the way these organs interact with each other.
This two-way communication is known as the gut-liver-brain axis. Gut microbiota has become a
key mechanism affecting the communication between gut and liver, gut and brain, and brain and
liver. The study of the microbiome-gut-liver-brain axis is helpful to deepen the understanding of
the pathogenesis of cirrhosis-related neuropsychiatric diseases and provide a direction for new
treatment methods. This article summarized the link between intestinal microbiota dysbiosis
and neuropsychiatric disorders associated with cirrhosis and evidence for the use of intestinal
microbiota regulation as a therapeutic approach in current clinical and preclinical studies.
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