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摘要：
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摘要：目的 探讨肝脏腺鳞癌的临床病理学特征、免疫表型、诊断及鉴别诊断。方法 回
顾性分析2020年1月1日至2023年4月30日于中国人民解放军联勤保障部队第九四〇医院
诊断为肝脏腺鳞癌的7例病例资料，其中2例为手术标本，5例为穿刺标本。采用大体检
查、镜检、HE染色、免疫组织化学染色等方法观察分析临床病理特征。结果 所有病例
标本的形态学及免疫组织化学均证实为肝脏鳞状细胞癌合并腺癌，其中鳞状细胞癌成
分表达P63、P40等，腺癌成分表达癌胚抗原（carcinoembryonic antigen，CEA）、细胞
角蛋白（cytokeratin，CK）7、CK19、CK8/18等。结论 肝脏腺鳞癌的病理诊断需要组
织学及免疫组织化学明确鳞状细胞癌与腺癌成分同时存在，具有独特的临床病理学特
征，同时需临床排除其他部位转移的可能。
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Abstract: Objective To investigate the clinicopathologic features, immunophenotypes, diagnoses
and differential diagnoses of hepatic adenosquamous carcinoma. Methods Total of 7 cases who were
diagnosed with hepatic adenosquamous carcinoma at the 940th Hospital of Joint Logistic Support Force
of Chinese People’s Liberation Army from January 1st, 2020 to April 30th, 2023 were retrospectively
analyzed. Among whom, 2 cases were surgical specimens and 5 cases were biopsy specimens. The
clinicopathological features were observed and analyzed by gross examination, microscopic examination,
HE staining and immunohistochemical staining. Results The morphological and immunohistochemical
features of all specimens confirmed a mixture of squamous cell carcinoma and adenocarcinoma. The
squamous cell carcinoma component expressed markers such as P63 and P40, while the adenocarcinoma
component expressed carcinoembryonic antigen (CEA), cytokeratin (CK) 7, CK19, and CK8/18, etc.
Conclusions The pathological diagnosis of hepatic adenosquamous carcinoma required both histological
and immunohistochemical confirmation of simultaneous presence of squamous cell carcinoma and
adenocarcinoma components, which exhibited distinct clinicopathological features. Additionally, clinical
exclusion of metastasis from other sites was necessary.
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