鞘脂在代谢相关脂肪性肝病中的研究进展

作者： color="#000000" face="楷体_GB2312"> style="font-size: 14px ">李妍华  赵翠娟  武文博

单位：内蒙古医科大学第三临床医学院（内蒙古包钢医院） 消化内科 内蒙古 包头 014000

关键词：代谢相关脂肪性肝病 神经酰胺 鞘氨醇1-磷酸 鞘氨醇（d18∶1）

分类号：

出版年,卷(期):页码：2025,17(4):6-10

摘要：

摘要：代谢相关脂肪性肝病（metabolic associated fatty liver disease，MAFLD）是一种常见 的慢性肝病，发病机制复杂。鞘脂代谢在MAFLD的发生发展中发挥重要作用。鞘脂代 谢异常可通过影响肝细胞脂质合成与转运、炎症反应、纤维化以及细胞凋亡等过程参与 MAFLD从单纯性脂肪肝向脂肪性肝炎、肝纤维化甚至肝硬化的进展。本文对鞘脂代谢途 径中的关键分子，如神经酰胺、鞘氨醇-1-磷酸、鞘氨醇等在MAFLD中的作用及机制以及 基于鞘脂代谢治疗MAFLD的潜在靶点和策略进行综述，以期为MAFLD防治提供新思路。

Abstract: Metabolic associated fatty liver disease (MAFLD) is a common chronic liver disease and its pathogenesis is complicated. Sphingolipid metabolism played a crucial role on the pathogenesis and progression of MAFLD. Dysregulation of sphingolipid metabolism contributed to the progression of MAFLD from simple fatty liver to steatohepatitis, liver fibrosis, and even cirrhosis by influencing processes such as hepatic lipid synthesis and transport, inflammatory responses, fibrosis and cell apoptosis. This article reviewed the roles and mechanisms of key molecules in the sphingolipid metabolic pathway in MAFLD, including ceramide, sphingosine-1-phosphate (S1P) and sphingosine, as well as potential therapeutic targets and strategies based on sphingolipid metabolism, with the aim of providing new insights for the prevention and treatment of MAFLD

基金项目：

作者简介：

参考文献：

服务与反馈：

【文章下载】【加入收藏】