酒精性肝病合并肌肉脂肪变性研究进展

作者： style="font-size: 12px ">王伊歌 1 杨松 2

单位：1. 青海大学 青海 西宁 810000 2. 中日友好医院 感染疾病科 北京 100029

关键词：酒精性肝病 肌肉脂肪变性 肌少症

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出版年,卷(期):页码：2026,18(1):25-29

摘要：

摘要：酒精性肝病（alcoholic liver disease，ALD）作为慢性肝病的重要病因之一，其 病理进程常伴随肌肉脂肪变性（muscle fat infiltration，MFI）这一关键代谢并发症， MFI 可显著加速疾病的进展并导致不良临床结局。ALD 合并 MFI 的相关机制尚未完全 明确，其中酒精及其代谢产物干扰线粒体功能导致骨骼肌质量下降和病理性脂质沉积 的机制已引起研究人员的关注。本文对 ALD 合并 MFI 的诊断标准、病理机制、预后关 联及多维度干预策略进行系统综述。

Abstract: Alcoholic liver disease (ALD) is one of the important causes of chronic liver disease. Its pathological process is often accompanied by muscle fat infiltration (MFI), a key metabolic complication, which can significantly accelerate disease progression and lead to adverse clinical outcomes. Although the underlying mechanisms of ALD complicated with MFI have not been fully elucidated, the mechanism by which alcohol and its metabolites interfere with mitochondrial function to cause reduced skeletal muscle mass and pathological lipid deposition has drawn widespread attention among researchers. The diagnostic criteria, pathological mechanisms, prognostic associations and multidimensional intervention strategies for ALD with MFI were reviewed in this paper.

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